YI / 111, Inc. - Depositary Receipt (Common Stock) - SEC提出書類- 年次報告書、委任状説明書

111, Inc. - 預託証券(普通株式)

基本統計
CIK 1738906
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to 111, Inc. - Depositary Receipt (Common Stock)
SEC Filings (Chronological Order)
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June 4, 2026 EX-99.1

111, Inc. Announces First Quarter 2026 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces First Quarter 2026 Unaudited Financial Results • Continuing Transition toward a More Asset-Light and Operationally Efficient Business Model • Net Revenue of Promotional Products (1) Increased by 70.2% and Gross Profit Rose by 75.0% Year-over-Year • Total Marketplace (MP) Service Revenue Increased by 24.7% Year-over-Year • Fulfillment Expenses as a Percentage of Rev

June 4, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2026 Commission file number: 001-38639 111, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2026 Commission file number: 001-38639 111, Inc. 10th Floor, T1, Yuzhongxin, No. 268 Yubei Road Pudong New Area Shanghai, 201204 The People’s Republic of China (Address of principal executive offices

April 30, 2026 EX-15.2

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 15.2 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated April 30, 2026, with respect to the consolidated financial statements included in the Annual Report of 111, Inc. on Form 20-F for the year ended December 31, 2025. We consent to the incorporation by reference of said report in the Registration Statements of 111, Inc. on Form S-8 No 333-229313. /s/

April 30, 2026 EX-12.2

Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.2 Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

April 30, 2026 EX-12.1

Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.1 Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

April 30, 2026 EX-15.1

Our ref

Exhibit 15.1 Our refKKZ/742474-000001/28733992v1 111, Inc. 3-5/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China April 30, 2026 Dear Sir and/or Madam 111, Inc. We have acted as legal advisers as to the laws of the Cayman Islands to 111, Inc., an exempted limited liability company incorporated in the Cayman Islands (the “Company”), in connection with the fil

April 30, 2026 EX-13.1

Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.1 Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2025 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, Chief Executive Officer of the Company, certify, pursuant to

April 30, 2026 EX-15.4

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 15.4 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in Registration Statement No. 333-229313 on Form S-8 of our report dated May 14, 2024, relating to the financial statements of 111, Inc., appearing in this Annual Report on Form 20-F for the year ended December 31, 2025. /s/ Deloitte Touche Tohmatsu Certified Public Accountants LLP Sh

April 30, 2026 EX-15.3

12-14th Floor, China World Office 2, No. 1 Jianguomenwai Avenue, Beijing 100004, China 电话 Tel: +86 10 6563 7181 传真 Fax: +86 10 6569 3838 电邮 Email: [email protected] 网址 Web: www.tongshang.com

Exhibit 15.3 中国北京建国门外大街1号国贸写字楼2座12-14层100004 12-14th Floor, China World Office 2, No. 1 Jianguomenwai Avenue, Beijing 100004, China 电话 Tel: +86 10 6563 7181 传真 Fax: +86 10 6569 3838 电邮 Email: [email protected] 网址 Web: www.tongshang.com April 30, 2026 111, Inc. 10th Floor, T1, Yuzhongxin, No. 268 Yubei Road, Pudong New Area Shanghai, 201204 The People’s Republic of China Dear Sirs, We consent t

April 30, 2026 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF

April 30, 2026 EX-13.2

Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.2 Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2025 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, acting in the capacity of Chief Financial Officer of the Com

April 9, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of April 2026 Commission file number: 001-38639 111, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of April 2026 Commission file number: 001-38639 111, Inc. 10th Floor, T1, Yuzhongxin, No. 268 Yubei Road Pudong New Area Shanghai, 201204 The People’s Republic of China (Address of principal executive office

April 9, 2026 EX-99.1

111, Inc. Announces Fourth Quarter and Fiscal Year 2025 Financial Results

Exhibit 99.1 111, Inc. Announces Fourth Quarter and Fiscal Year 2025 Financial Results · Continuing Transition to an Asset-Light Business Model to Improve Overall Efficiency · Delivered Non-GAAP Operating Profitability in Both Q4'25 and FY'25 · Generated Positive Operating Cash Flow for Both Q4'25 and FY'25 · Continued Gross Profit Margin Expansion for B2B Business in Both Q4’25 and FY'25 SHANGHAI

December 17, 2025 EX-99.1

111, Inc. Announces Third Quarter 2025 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Third Quarter 2025 Unaudited Financial Results · Transition from An Asset-Heavy Business Model to An Asset-Light Business Model · Achieved Quarterly Non-GAAP Net Profitability · Maintained Non-GAAP Operational Profitability for Three Consecutive Quarters · Achieved Quarterly Positive Operating Cash Flow SHANGHAI, December 17, 2025 /PRNewswire/ – 111, Inc. (“111” or

December 17, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2025 Commission file number: 001-38639 111, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2025 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate b

September 17, 2025 EX-99.1

111, Inc. Announces Second Quarter 2025 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Second Quarter 2025 Unaudited Financial Results • Maintained Quarterly Operational Profitability • Operating Expenses as a Percentage of Revenues Decreased 20 Basis Points YoY • Maintained Positive Operating Cash Flow in the First Half of the Year SHANGHAI, September 17, 2025 /PRNewswire/ – 111, Inc. (“111” or the “Company”) (NASDAQ: YI), a leading tech-enabled hea

September 17, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2025 Commission file number: 001-38639 111,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2025 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate

September 4, 2025 LETTER

LETTER

September 4, 2025 Junling Liu Chief Executive Officer and Co-Chairman of the Board 111, Inc.

August 29, 2025 EX-15.4

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 15.4 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in this Registration Statement No. 333-229313 on Form S-8 of our report dated May 14, 2024, relating to the financial statements of 111, Inc., appearing in the Annual Report on Form 20-F/A of 111, Inc. for the year ended December 31, 2024. /s/ Deloitte Touche Tohmatsu Certified Public

August 29, 2025 EX-12.1

Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.1 Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F, as amended by Amendment No. 1 thereto, of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make t

August 29, 2025 20-F/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F/A (Amendment No. 1)

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F/A (Amendment No. 1) (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SEC

August 29, 2025 EX-13.2

Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.2 Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2024 as filed with the Securities and Exchange Commission on April 29, 2025, as amended by Amendment No. 1 thereto (the “Report”), I, Junling Liu, acting in the capacity

August 29, 2025 EX-13.1

Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.1 Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2024 as filed with the Securities and Exchange Commission on April 29, 2025, as amended by Amendment No. 1 thereto (the “Report”), I, Junling Liu, Chief Executive Office

August 29, 2025 CORRESP

2

August 29, 2025 Division of Corporation Finance U.S. Securities & Exchange Commission 100 F Street, NE Washington, D.C. 20549 Re: 111, Inc. Annual Report on Form 20-F Filed April 29, 2025 File No. 001-38639 Attn: Division of Corporation Finance Office of Trade & Services VIA EDGAR Dear Blaise Rhodes and Rufus Decker: This letter sets forth the responses of 111, Inc. (the “Company”) to the comments

August 29, 2025 EX-12.2

Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.2 Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F, as amended by Amendment No. 1 thereto, of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make t

August 22, 2025 CORRESP

111, Inc.

August 22, 2025 Division of Corporation Finance U.S. Securities & Exchange Commission 100 F Street, NE Washington, D.C. 20549 Re: 111, Inc. Annual Report on Form 20-F Filed April 29, 2025 File No. 001-38639 Attn: Division of Corporation Finance Office of Trade & Services VIA EDGAR Dear Blaise Rhodes and Rufus Decker: 111, Inc. (the “Company”) acknowledges receipt of a comment letter from the staff

August 11, 2025 LETTER

LETTER

August 11, 2025 Junling Liu Chief Executive Officer and Co-Chairman of the Board 111, Inc.

August 6, 2025 CORRESP

2

August 6, 2025 Division of Corporation Finance U.S. Securities & Exchange Commission 100 F Street, NE Washington, D.C. 20549 Re: 111, Inc. Annual Report on Form 20-F Filed April 29, 2025 File No. 001-38639 Attn: Division of Corporation Finance Office of Trade & Services VIA EDGAR Dear Blaise Rhodes and Rufus Decker: This letter sets forth the responses of 111, Inc. (the “Company”) to the comments

July 24, 2025 LETTER

LETTER

July 24, 2025 Junling Liu Chief Executive Officer and Co-Chairman of the Board 111, Inc.

June 20, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2025 Commission file number: 001-38639 111, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2025 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate by ch

June 20, 2025 EX-99.1

111, Inc. Announces First Quarter 2025 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces First Quarter 2025 Unaudited Financial Results · Maintained Quarterly Operational Profitability · Operating Expenses as a Percentage of Revenues Decreased 30 Basis Points YoY · Maintained Quarterly Positive Operating Cash Flow SHANGHAI, June 19, 2025 /PRNewswire/ – 111, Inc. (“111” or the “Company”) (NASDAQ: YI), a leading tech-enabled healthcare platform company c

April 29, 2025 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF

April 29, 2025 EX-15.2

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 15.2 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We have issued our report dated April 29, 2025, with respect to the consolidated financial statements included in the Annual Report of 111, Inc. on Form 20-F for the year ended December 31, 2024. We consent to the incorporation by reference of said report in the Registration Statements of 111, Inc. on Form S-8 No 333-229313. /s/

April 29, 2025 EX-15.4

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 15.4 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in this Registration Statement No. 333-229313 on Form S-8 of our report dated May 14, 2024, relating to the financial statements of 111, Inc., appearing in the Annual Report on Form 20-F of 111, Inc. for the year ended December 31, 2024. /s/ Deloitte Touche Tohmatsu Certified Public A

April 29, 2025 EX-12.2

Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.2 Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

April 29, 2025 EX-2.4

Description of Rights of Each Class of Securities Registered under Section 12 of the Securities Exchange Act of 1934 (the “Exchange Act”)

Exhibit 2.4 Description of Rights of Each Class of Securities Registered under Section 12 of the Securities Exchange Act of 1934 (the “Exchange Act”) American Depositary Shares (“ADSs”) each representing twenty Class A ordinary shares of 111, Inc., (the “we,” “our,” “our company,” or “us”) are listed and traded on the Nasdaq Global Market and, in connection with this listing (but not for trading),

April 29, 2025 EX-13.1

Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.1 Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2024 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, Chief Executive Officer of the Company, certify, pursuant to

April 29, 2025 EX-15.3

12-14th Floor, China World Office 2, No. 1 Jianguomenwai Avenue, Beijing 100004, China 电话 Tel: +86 10 6563 7181 传真 Fax: +86 10 6569 3838 电邮 Email: [email protected] 网址 Web: www.tongshang.com

Exhibit 15.3 中国北京建国门外大街1号国贸写字楼2座12-14层100004 12-14th Floor, China World Office 2, No. 1 Jianguomenwai Avenue, Beijing 100004, China 电话 Tel: +86 10 6563 7181 传真 Fax: +86 10 6569 3838 电邮 Email: [email protected] 网址 Web: www.tongshang.com April 29, 2025 111, Inc. 3-4/F, No. 295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China Dear Sirs, We consent to the reference

April 29, 2025 EX-12.1

Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.1 Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

April 29, 2025 EX-15.1

Our ref

Exhibit 15.1 Our ref KKZ/742474-000001/28733992v1 111, Inc. 3-5/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China 29 April 2025 Dear Sir and/or Madam 111, Inc. We have acted as legal advisers as to the laws of the Cayman Islands to 111, Inc., an exempted limited liability company incorporated in the Cayman Islands (the “Company”), in connection with the fil

April 29, 2025 EX-13.2

Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.2 Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2024 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, acting in the capacity of Chief Financial Officer of the Com

April 29, 2025 EX-11.2

111, INC. STATEMENT OF POLICIES GOVERNING MATERIAL NON-PUBLIC INFORMATION AND THE PREVENTION OF INSIDER TRADING (Adopted by the Board of Directors of 111, Inc. on AUGUST 21, 2018, effective upon the effectiveness of its registration statement on Form

Exhibit 11.2 111, INC. STATEMENT OF POLICIES GOVERNING MATERIAL NON-PUBLIC INFORMATION AND THE PREVENTION OF INSIDER TRADING (Adopted by the Board of Directors of 111, Inc. on AUGUST 21, 2018, effective upon the effectiveness of its registration statement on Form F-1 relating to its initial public offering) This Statement of Policies Governing Material Non-Public Information and the Prevention of

March 20, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2025 Commission file number: 001-38639 111, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2025 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate by c

March 20, 2025 EX-99.1

111, Inc. Announces Fourth Quarter and Fiscal Year 2024 Financial Results

Exhibit 99.1 111, Inc. Announces Fourth Quarter and Fiscal Year 2024 Financial Results • Achieved First-Ever Annual Operating Profit • Bottom Line Improved by RMB332.7 Million YoY in 2024 • Operating Expenses as a Percentage of Revenues Decreased 230 Basis Points YoY in 2024 • Q4’24 Operating Expenses as a Percentage of Revenues Decreased 470 Basis Points YoY • Achieved First-Ever Annual Positive

February 11, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2025 Commission file number: 001-38639 111, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2025 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate b

February 11, 2025 EX-99.1

111, Inc. Regains Compliance with NASDAQ Requirement

Exhibit 99.1 111, Inc. Regains Compliance with NASDAQ Requirement SHANGHAI, February 11, 2025 /PRNewswire/ – 111, Inc. (NASDAQ: YI) (“111” or the “Company”), a leading tech-enabled healthcare platform company committed to reshaping the value chain of healthcare industry by digitally empowering the upstream and downstream in China, announced today that it has received notification from The Nasdaq S

January 8, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of January 2025 Commission file number: 001-38639 111, In

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of January 2025 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate by

January 8, 2025 EX-99.1

111, Inc. Announces ADS Ratio Change

Exhibit 99.1 111, Inc. Announces ADS Ratio Change SHANGHAI, January 8, 2025 /PRNewswire/ - 111, Inc. (“111” or the “Company”) (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to reshaping the value chain of healthcare industry by digitally empowering the upstream and downstream in China, today announced that it plans to change the ratio of its American Depositary Shares (

November 27, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2024 Commission file number: 001-38639 111, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2024 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate b

November 27, 2024 EX-99.1

111, Inc. Announces Third Quarter 2024 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Third Quarter 2024 Unaudited Financial Results · Maintained Operational Profitability for the Third Consecutive Quarter · Operating Expenses as a Percentage of Revenues Decreased 160 Basis Points YoY · Held Positive Operating Cash Flow for Three Consecutive Quarters SHANGHAI, November 27, 2024 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leadin

November 4, 2024 EX-99.1

111, Inc. Announces Change to Board of Directors

Exhibit 99.1 111, Inc. Announces Change to Board of Directors SHANGHAI, November 4, 2024 /PRNewswire/ - 111, Inc. (“111” or the “Company”) (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to reshaping the value chain of healthcare industry by digitally empowering the upstream and downstream in China, today announced that Dr. Leon Lian Yong Chen has tendered his resignatio

November 4, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2024 Commission file number: 001-38639 111, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2024 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate b

August 29, 2024 EX-99.1

111, Inc. Announces Second Quarter 2024 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Second Quarter 2024 Unaudited Financial Results • Maintained Operational Profitability for the Second Consecutive Quarter • Operating Expenses as a Percentage of Revenues Decreased 120 Basis Points YoY • Held Positive Operating Cash Flow for Two Consecutive Quarters SHANGHAI, August 29, 2024 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading

August 29, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2024 Commission file number: 001-38639 111, Inc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2024 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate by

July 19, 2024 EX-16.1

Deloitte Touche Tohmatsu

Exhibit 16.1 Deloitte Touche Tohmatsu Certified Public Accountants LLP 30/F Bund Center 222 Yan An Road East Shanghai 200002, PRC Tel: +86 21 6141 8888 Fax: +86 21 6335 0003 www.deloitte.com/cn July 19, 2024 Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549-7561 Dear Sirs/Madams: We have read 111, Inc.’s Form 6-K dated July 19, 2024, and have the following comments: 1. W

July 19, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN -PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of July 2024 Commission File Number: 001-38639 1

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN -PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of July 2024 Commission File Number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indic

May 23, 2024 EX-99.1

111, Inc. Announces First Quarter 2024 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces First Quarter 2024 Unaudited Financial Results • Turned to Quarterly Operational Profitability for the First Time • Operating Expenses as a Percentage of Revenues Decreased 120 Basis Points YoY to 5.8% • Achieved Positive Operating Cash Flow SHANGHAI, May 23, 2024 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare plat

May 23, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2024 Commission file number: 001-38639 111, Inc. 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2024 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate by che

May 14, 2024 EX-12.1

Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.1 Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

May 14, 2024 EX-15.2

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 15.2 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in Registration Statement No. 333-229313 on Form S-8 of our reports dated May 14, 2024, relating to the financial statements of 111, Inc. and the effectiveness of 111, Inc.’s internal control over financial reporting appearing in this Annual Report on Form 20-F for the year ended Dece

May 14, 2024 EX-15.3

12-14th Floor, China World Office 2, No. 1 Jianguomenwai Avenue, Beijing 100004, China 电话 Tel: +86 10 6563 7181 传真 Fax: +86 10 6569 3838 电邮 Email: [email protected] 网址 Web: www.tongshang.com

Exhibit 15.3 中国北京建国门外大街1号国贸写字楼2座12-14层100004 12-14th Floor, China World Office 2, No. 1 Jianguomenwai Avenue, Beijing 100004, China 电话 Tel: +86 10 6563 7181 传真 Fax: +86 10 6569 3838 电邮 Email: [email protected] 网址 Web: www.tongshang.com May 14, 2024 111, Inc. 3-4/F, No. 295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China Dear Sirs, We consent to the reference to

May 14, 2024 EX-12.2

Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.2 Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

May 14, 2024 EX-15.1

Our ref

Exhibit 15.1 Our refKKZ/742474-000001/28733992v1 111, Inc. 3-5/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China May 9, 2024 Dear Sir and/or Madam 111, Inc. We have acted as legal advisers as to the laws of the Cayman Islands to 111, Inc., an exempted limited liability company incorporated in the Cayman Islands (the “Company”), in connection with the filing

May 14, 2024 EX-13.2

Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.2 Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2022 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, acting in the capacity of Chief Financial Officer of the Com

May 14, 2024 EX-13.1

Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.1 Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2022 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, Chief Executive Officer of the Company, certify, pursuant to

May 14, 2024 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF

May 14, 2024 EX-97

111, Inc. COMPENSATION RECOUPMENT POLICY

Exhibit 97 111, Inc. COMPENSATION RECOUPMENT POLICY This 111, Inc. Compensation Recoupment Policy (the “Policy”) has been adopted by the Board of Directors (the “Board”) of 111, Inc. (the “Company”) on September 7, 2023. This Policy provides for the recoupment of certain executive compensation in the event of an accounting restatement resulting from material noncompliance with financial reporting

April 30, 2024 NT 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 12b-25 NOTIFICATION OF LATE FILING (Checkone): ☐ Form 10-K ☒ Form 20-F ☐ Form 11-K ☐ Form 10-Q ☐ Form 10-D ☐ Form N-CEN ☐ Form N-CSR For Period Ended: December 31, 2023 ☐ Transition Report on Form 10-K ☐ Transition Report on Form 20-F ☐ Transition Report on Form 11-K ☐ Transition Report on Form 10-Q For the Transition Per

March 21, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2024 Commission file number: 001-38639 111, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2024 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate by c

March 21, 2024 EX-99.1

111, Inc. Announces Fourth Quarter and Fiscal Year 2023 Financial Results

Exhibit 99.1 111, Inc. Announces Fourth Quarter and Fiscal Year 2023 Financial Results SHANGHAI, March 21, 2024 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the fourth quarter and fiscal

February 27, 2024 SC 13D/A

YI / 111, Inc. - Depositary Receipt (Common Stock) / Gang Yu - SC 13D/A Activist Investment

SC 13D/A 1 tm245448d1sc13da.htm SC 13D/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 3)* 111, INC. (Name of Issuer) Class A ordinary shares, $0.00005 par value per share Class B ordinary shares, $0.00005 par value per share (Title of Class of Securities) 68247Q 102** (CUSIP Number) Gang Yu Xiaomei M

February 27, 2024 EX-99.3

Termination Agreement

EX-99.3 2 tm245448d1ex99-3.htm EXHIBIT 99.3 Exhibit 99.3 Termination Agreement This Termination Agreement (“Termination Agreement”) is made and entered into dated February 27, 2024, by and among each undersigned. Reference is hereby made to the Statement of Beneficial Ownership on Schedule 13D filed with the Securities and Exchange Commission by the Parties (as amended to date, the “Schedule 13D”)

February 27, 2024 EX-99.1

111 Announces Receipt of Withdrawal of Going Private Proposal

Exhibit 99.1 111 Announces Receipt of Withdrawal of Going Private Proposal 111, Inc. (“111” or the “Company”) (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced that it has received a notice dated Feburary 27, 2024 on behalf of the consortium comprising Dr. Gang Yu, co-founder a

February 27, 2024 EX-99.24

TERMINATION AGREEMENT

EX-99.24 3 tm245448d1ex99-24.htm EXHIBIT 99.24 Exhibit 99.24 TERMINATION AGREEMENT THIS TERMINATION AGREEMENT, dated as of February 27, 2024 (this “Agreement”), is made by and among: A. Dr. Gang Yu, a U.S. citizen and the co-founder and co-chairman of the Company (as defined below), B. Mr. Junling Liu, an Australian citizen and the co-founder, co-chairman and chief executive officer of the Company

February 27, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2024 Commission file number: 001-38639 111, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2024 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate b

November 30, 2023 EX-99.1

111, Inc. Announces Third Quarter 2023 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Third Quarter 2023 Unaudited Financial Results SHANGHAI, November 30, 2023 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the third quarter ended September

November 30, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2023 Commission file number: 001-38639 111, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2023 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate b

August 24, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2023 Commission file number: 001-38639 111, Inc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2023 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate by

August 24, 2023 EX-99.1

111, Inc. Announces Second Quarter 2023 Unaudited Financial Results

111, Inc. Announces Second Quarter 2023 Unaudited Financial Results SHANGHAI, August 24, 2023 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the second quarter ended June 30, 2023. Second Q

August 14, 2023 LETTER

LETTER

United States securities and exchange commission logo August 14, 2023 Junling Liu Chief Executive Officer 111, Inc.

August 1, 2023 CORRESP

111, Inc.

August 1, 2023 Division of Corporation Finance U.S. Securities & Exchange Commission 100 F Street, NE Washington, D.C. 20549 Re: 111, Inc. Annual Report on Form 20-F Response Dated September 27, 2022 File No. 001-38639 Attn: Division of Corporation Finance Office of Trade & Services VIA EDGAR Dear Kyle Wiley and Jennifer Thompson: This letter sets forth the responses of 111, Inc. (the “Company”) t

July 21, 2023 LETTER

LETTER

United States securities and exchange commission logo July 21, 2023 Junling Liu Chief Executive Officer 111, Inc.

July 17, 2023 SC 13D/A

YI / 111 Inc - ADR / Gang Yu - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 2)* 111, INC. (Name of Issuer) Class A ordinary shares, $0.00005 par value per share Class B ordinary shares, $0.00005 par value per share (Title of Class of Securities) 68247Q 102** (CUSIP Number) Gang Yu Xiaomei Michelle Song Infinity Cosmo Limited Junli

July 17, 2023 EX-99.16

AMENDED AND RESTATED CONSORTIUM AGREEMENT

Exhibit 99.16 AMENDED AND RESTATED CONSORTIUM AGREEMENT THIS AMENDED AND RESTATED CONSORTIUM AGREEMENT, dated as of July 17, 2023 (this “Agreement”, including all schedules annexed hereto, as hereafter from time to time amended, modified, supplemented, renewed or replaced), is made by and among: A. Dr. Gang Yu, a U.S. citizen and the co-founder and co-chairman of the Company (“Dr. Yu”), B. Mr. Jun

July 17, 2023 EX-99.22

DEED OF ADHERENCE

Exhibit 99.22 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on July 17, 2023 BY: SAIF Partners (Nanjing) Equity Investment Fund (LP), a limited partnership organized and existing under the laws of People’s Republic of China with its registered address at Wei Ke Space C28, Yangzijiang New Financial Creative Block, No. 396 Binjiang Avenue, Nanjing Area, China (Jiangsu) Pilot

July 17, 2023 EX-99.23

DEED OF ADHERENCE

Exhibit 99.23 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on July 17, 2023 BY: SAIF Partners (Nanjing) Hengzhun Venture Capital Fund (LP), a limited partnership organized and existing under the laws of People’s Republic of China with its registered address at No. 2-3, Zidong Road, Maqun Street, Qixia District, Nanjing (the “Additional Member”). RECITALS: (A) On July 17,

July 17, 2023 EX-99.20

DEED OF ADHERENCE

Exhibit 99.20 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on July 17, 2023 BY: Hangzhou Huazhi Capital lnvestment Management Co., Ltd., a limited liability company organized and existing under the laws of People’s Republic of China with its registered address at Room 528, No.88,Yuan Shuai Miao Hou, Shangcheng District, Hangzhou City, Zhejiang Province, China (the “Additi

July 17, 2023 EX-99.18

DEED OF ADHERENCE

Exhibit 99.18 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on July 17, 2023 BY: Shanghai Youwei Genilink Capital Management Limited, a limited liability company organized and existing under the laws of People’s Republic of China with its registered address at 4th Floor, No. 391-393(Odd Number), Dongdaming Road, Hongkou District, Shanghai (Centralized registration Place) (

July 17, 2023 EX-99.19

DEED OF ADHERENCE

Exhibit 99.19 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on July 17, 2023 BY: Vendavel Investment SPC acting on behalf of Global Opportunity Fund SP, a segregated portfolio formed by Vendavel Investment SPC, a segregated portfolio company existing under the laws of the Cayman Islands with its registered address at Fifth Floor, Zephyr House22 Mary Street, George Town, P.

July 17, 2023 EX-99.3

JOINT FILING AGREEMENT

Exhibit 99.3 JOINT FILING AGREEMENT In accordance with Rule 13d-(k)(l) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree (i) to the joint filing, on behalf of each of them, of a statement on Schedule 13D (including amendments thereto) with respect to the shares of 111, Inc., an exempted company with limited liability registered under the laws of the Ca

July 17, 2023 EX-99.21

DEED OF ADHERENCE

Exhibit 99.21 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on July 17, 2023 BY: Suzhou Kunjie Venture Capital Partnership (Limited Partnership), a limited partnership organized and existing under the laws of People’s Republic of China with its registered address at Building 38, Suzhou Bay Oriental Venture Capital Base, No. 333 Yingbin Avenue, Wujiang District, Suzhou (the

July 17, 2023 EX-99.17

DEED OF ADHERENCE

Exhibit 99.17 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on July 17, 2023 BY: ALLIED CHINA INVESTMENT LIMITED, a limited liability company organized and existing under the laws of Hong Kong SAR with its registered address at Unit 2308, 23/F, Tower A Pingan IFC, 01-03 Xinyuannanlu, Chaoyang District, Beijing 100027, China (the “Additional Member”). RECITALS: (A)         

June 15, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2023 Commission file number: 001-38639 111, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2023 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate by ch

June 15, 2023 EX-99.1

111, Inc. Announces First Quarter 2023 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces First Quarter 2023 Unaudited Financial Results SHANGHAI, June 15, 2023 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the first quarter ended March 31, 2023

April 28, 2023 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF

April 28, 2023 EX-16.1

April 28, 2023

Exhibit 16.1 April 28, 2023 VIA EDGAR Division of Corporation Finance U.S. Securities & Exchange Commission 100 F Street, NE Washington, D.C. 20549 Re: 111, Inc. Submission under the Item 16I(a) of Form 20-F Attn: Division of Corporation Finance Office of Life Sciences Dear Sir/Madam, In compliance with the Holding Foreign Companies Accountable Act, 111, Inc. (the “Company”) is submitting via EDGA

April 28, 2023 EX-13.2

Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.2 Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2022 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, acting in the capacity of Chief Financial Officer of the Com

April 28, 2023 EX-12.2

Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.2 Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

April 28, 2023 EX-12.1

Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.1 Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

April 28, 2023 EX-15.3

12-14th Floor, China World Office 2, No. 1 Jianguomenwai Avenue, Beijing 100004, China 电话 Tel: +86 10 6563 7181 传真 Fax: +86 10 6569 3838 电邮 Email: [email protected] 网址 Web: www.tongshang.com

Exhibit 15.3 中国北京建国门外大街1号国贸写字楼2座12-14层100004 12-14th Floor, China World Office 2, No. 1 Jianguomenwai Avenue, Beijing 100004, China 电话 Tel: +86 10 6563 7181 传真 Fax: +86 10 6569 3838 电邮 Email: [email protected] 网址 Web: www.tongshang.com April 28, 2023 111, Inc. 3-5/F, No. 295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China Dear Sirs, We consent to the reference

April 28, 2023 EX-15.1

Our ref

Exhibit 15.1 Our refKKZ/742474-000001/25878602v2 111, Inc. 3-5/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China April 28, 2023 Dear Sir and/or Madam 111, Inc. We have acted as legal advisers as to the laws of the Cayman Islands to 111, Inc., an exempted limited liability company incorporated in the Cayman Islands (the “Company”), in connection with the fil

April 28, 2023 EX-13.1

Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.1 Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2022 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, Chief Executive Officer of the Company, certify, pursuant to

April 28, 2023 EX-15.2

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 15.2 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in Registration Statement No. 333-229313 on Form S-8 of our reports dated April 28, 2023, relating to the financial statements of 111, Inc. and the effectiveness of 111, Inc.’s internal control over financial reporting which appear in 111, Inc.’s Annual Report on Form 20-F for the yea

March 27, 2023 LETTER

LETTER

United States securities and exchange commission logo March 27, 2023 Junling Liu Chief Executive Officer 111, Inc.

March 23, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2023 Commission file number: 001-38639 111, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2023 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate by c

March 23, 2023 EX-99.1

111, Inc. Announces Fourth Quarter and Fiscal Year 2022 Financial Results

Exhibit 99.1 111, Inc. Announces Fourth Quarter and Fiscal Year 2022 Financial Results SHANGHAI, March 23, 2023 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the fourth quarter and fiscal

January 31, 2023 CORRESP

2

CORRESP 1 filename1.htm January 31, 2023 Division of Corporation Finance U.S. Securities & Exchange Commission 100 F Street, NE Washington, D.C. 20549 Re: 111, Inc. Annual Report on Form 20-F Response Dated September 27, 2022 File No. 001-38639 Attn: Division of Corporation Finance Office of Trade & Services VIA EDGAR Dear Jennie Beysolow and Erin Jaskot: This letter sets forth the responses of 11

January 18, 2023 LETTER

LETTER

United States securities and exchange commission logo January 18, 2023 Junling Liu Chief Executive Officer 111, Inc.

December 1, 2022 EX-99.1

111, Inc. Announces Third Quarter 2022 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Third Quarter 2022 Unaudited Financial Results SHANGHAI, December 1, 2022 /PRNewswire/ ? 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the third quarter ended September 3

December 1, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2022 Commission file number: 001-38639 111, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2022 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People?s Republic of China (Address of principal executive offices) Indicate b

October 31, 2022 EX-99.4

DEED OF ADHERENCE

Exhibit 99.4 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on October 29, 2022 BY: 6 Dimensions Capital, L.P., an exempted limited partnership organized and existing under the laws of Cayman Islands with its registered address at c/o Maples Corporate Services Limited of PO Box 309, Ugland House, Grand Cayman, KY1-1104, Cayman Islands (the “Additional Member”). RECITALS: (A

October 31, 2022 EX-99.13

DEED OF ADHERENCE

Exhibit 99.13 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on October 29, 2022 BY: Shanghai Changfeng Huixin Equity Investment Fund Management Co., Ltd., a limited liability company organized and existing under the laws of People’s Republic of China with its registered address at Room 304, 305, Building 248, 345 Yunling East Road, Putuo District, Shanghai, PRC (the “Addit

October 31, 2022 EX-99.10

Exhibit 99.10: Deed of Adherence by First Pharmacia International, dated October 29, 2022

Exhibit 99.10 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on October 29, 2022 BY: First Pharmacia International, a limited liability company organized and existing under the laws of Cayman Islands with its registered address at Walkers Corporate Limited, 190 Elgin Avenue, George Town, Grand Cayman KY1-9008, Cayman Islands (the “Additional Member”). RECITALS: (A) On Septe

October 31, 2022 SC 13D/A

YI / 111, Inc. / Gang Yu - SC 13D/A Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D/A Under the Securities Exchange Act of 1934 (Amendment No. 1)* 111, INC. (Name of Issuer) Class A ordinary shares, $0.00005 par value per share Class B ordinary shares, $0.00005 par value per share (Title of Class of Securities) 68247Q 102** (CUSIP Number) Gang Yu Xiaomei Michelle Song Infinity Cosmo Limited Junli

October 31, 2022 EX-99.7

Exhibit 99.7: Deed of Adherence by ClearVue Partners, L.P., dated October 29, 2022

Exhibit 99.7 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on October 29, 2022 BY: ClearVue Partners, L.P., an exempted limited partnership organized and existing under the laws of Cayman Islands with its registered address at 4th Floor, Harbour Place, 103 South Church Street, P.O. Box 10240, Grand Cayman KY1-1002, Cayman Islands (the “Additional Member”). RECITALS: (A) On

October 31, 2022 EX-99.3

Exhibit 99.3: Joint Filing Agreement among the Reporting Persons, dated October 31, 2022

Exhibit 99.3 JOINT FILING AGREEMENT In accordance with Rule 13d-(k)(l) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree (i) to the joint filing, on behalf of each of them, of a statement on Schedule 13D (including amendments thereto) with respect to the shares of 111, Inc., an exempted company with limited liability registered under the laws of the Ca

October 31, 2022 EX-99.15

[signatures page follows]

Exhibit 99.15 October 29, 2022 The Special Committee of Board of Directors (the “Special Committee”) 111, Inc. (the “Company”) 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China Dear members of the Special Committee: Reference is made to the preliminary non-binding proposal (the “Original Proposal”), dated as of September 9, 2022, from Dr. Gang Yu, co-fo

October 31, 2022 EX-99.12

DEED OF ADHERENCE

Exhibit 99.12 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on October 29, 2022 BY: Morning Star Resources Limited, a limited liability company organized and existing under the laws of British Virgin Islands, with its registered address at Wickhams Cay II, Road Town, Tortola, VG1110, British Virgin Islands (the “Additional Member”). RECITALS: (A) On September 9, 2022, the

October 31, 2022 EX-99.6

Exhibit 99.6: Deed of Adherence by ClearVue YW Holdings, Ltd., dated October 29, 2022

Exhibit 99.6 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on October 29, 2022 BY: ClearVue YW Holdings, Ltd., an exempted company organized and existing under the laws of Cayman Islands with its registered address at 4th Floor, Harbour Place, 103 South Church Street, P.O. Box 10240, Grand Cayman KY1-1002, Cayman Islands (the “Additional Member”). RECITALS: (A) On Septembe

October 31, 2022 EX-99.5

Exhibit 99.5: Deed of Adherence by 6 Dimensions Affiliates Fund, L.P., dated October 29, 2022

Exhibit 99.5 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on October 29, 2022 BY: 6 Dimensions Affiliates Fund, L.P., an exempted limited partnership organized and existing under the laws of Cayman Islands with its registered address at c/o Maples Corporate Services Limited of PO Box 309, Ugland House, Grand Cayman, KY1-1104, Cayman Islands (the “Additional Member”). RECI

October 31, 2022 EX-99.11

Exhibit 99.11: Deed of Adherence by J.P. Morgan Trust Company of Delaware, as trustee of Hodge Mountain 2020 Irrevocable Trust, dated October 29, 2022

Exhibit 99.11 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on October 29, 2022 BY: J.P. Morgan Trust Company of Delaware, a corporation incorporated under the laws of Delaware as the trustee for and on behalf of Hodge Mountain 2020 Irrevocable Trust (the “Additional Member”). RECITALS: (A) On September 9, 2022, the parties listed on Annex A to this Deed (the “Existing Mem

October 31, 2022 EX-99.14

DEED OF ADHERENCE

Exhibit 99.14 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on October 29, 2022 BY: Ningbo Youkai Venture Capital Partnership (Limited Partnership), a limited partnership organized and existing under the laws of People’s Republic of China with its registered address at Room 109, Building 13, Zhihuijiayuan, Xiangbao Cooperation Zone, Ningbo, Zhejiang Province, China (the “A

October 31, 2022 EX-99.8

DEED OF ADHERENCE

Exhibit 99.8 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on October 29, 2022 BY: Zall Capital Limited, a limited liability company organized and existing under the laws of British Virgin Islands with its registered address at OMC Chambers, Wickhams Cay 1, Road Town, Tortola, British Virgin Islands (the “Additional Member”). RECITALS: (A) On September 9, 2022, the parties

October 31, 2022 EX-99.9

Exhibit 99.9: Deed of Adherence by Tongyi Investment Holdings Limited, dated October 29, 2022

Exhibit 99.9 DEED OF ADHERENCE This Deed of Adherence (this “Deed”) is entered into on October 29, 2022 BY: Tongyi Investment Holdings Limited, a limited liability company organized and existing under the laws of Cayman with its registered address at Sertus Chambers, Governors Square, Suite # 5-204, 23 Lime Tree Bay Avenue, P.O. Box 2547, Grand Cayman, KY1-1104, Cayman Islands (the “Additional Mem

September 27, 2022 CORRESP

Division of Corporation Finance

CORRESP 1 filename1.htm September 27, 2022 Division of Corporation Finance U.S. Securities & Exchange Commission 100 F Street, NE Washington, D.C. 20549 Re: 111, Inc. Annual Report on Form 20-F Filed April 29, 2022 File No. 001-38639 Attn: Division of Corporation Finance Office of Trade & Services VIA EDGAR Dear Jennie Beysolow and Erin Jaskot: This letter sets forth the responses of 111, Inc. (“1

September 23, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2022 Commission file number: 001-38639 111,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2022 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People?s Republic of China (Address of principal executive offices) Indicate

September 23, 2022 EX-99.1

111, Inc. Announces Appointment of Independent Financial Advisor and Legal Counsel to the Special Committee

EXHIBIT 99.1 111, Inc. Announces Appointment of Independent Financial Advisor and Legal Counsel to the Special Committee SHANGHAI, September 23, 2022 /PRNewswire/ - 111, Inc. ( "111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company in China, announced today that the special committee (the ?Special Committee?), consisting of three independent directors, Mr. Jian Su

September 23, 2022 CORRESP

Ms. Jennie Beysolow

CORRESP 1 filename1.htm September 23, 2022 Ms. Jennie Beysolow Ms. Erin Jaskot Division of Corporation Finance Securities and Exchange Commission 100 F Street, N.E. Mail Stop 4628 Washington, D.C. 20549 U.S.A. Re: 111, Inc. Form 20-F for Fiscal Year Ended December 31, 2021 Filed April 29, 2022 Dear Jennie Beysolow and Erin Jaskot: 111, Inc. (the “Company”) acknowledges receipt of a comment letter

September 9, 2022 EX-99.1

CONSORTIUM AGREEMENT

Exhibit 99.1 Execution Version CONSORTIUM AGREEMENT THIS CONSORTIUM AGREEMENT, dated as of September 9, 2022 (this ?Agreement?), is made by and among A. Dr. Gang Yu, a U.S. citizen and the co-founder and co-chairman of the Company (?Dr. Yu?), B. Mr. Junling Liu, an Australian citizen and the co-founder, co-chairman and chief executive officer of the Company (?Mr. Liu?, and together with Dr. Yu, th

September 9, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2022 Commission file number: 001-38639 111,

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2022 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People?s Republic of China (Address of principal executive offices) Indicate

September 9, 2022 EX-99.1

1

EXHIBIT 99.1 111 Inc. Receives Unsolicited Preliminary Non-Binding Proposal to Acquire the Company SHANGHAI, September 9, 2022 /PRNewswire/ - 111 Inc. ( "111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company in China, today announced that its Board of Directors (the "Board") has received an unsolicited preliminary non-binding proposal letter (the "Proposal") dated

September 9, 2022 EX-99.3

JOINT FILING AGREEMENT

Exhibit 99.3 JOINT FILING AGREEMENT In accordance with Rule 13d-(k)(l) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree (i) to the joint filing, on behalf of each of them, of a statement on Schedule 13D (including amendments thereto) with respect to the shares of 111, Inc., an exempted company with limited liability registered under the laws of the Ca

September 9, 2022 EX-99.2

Exhibit 99.2: Proposal Letter from Gang Yu, Junling Liu, and Shanghai Guosheng Capital Management Co., Ltd. to the Board of Directors of 111, Inc., dated September 9, 2022

Exhibit 99.2 September 9, 2022 Board of Directors (the ?Board?) 111, Inc. (the ?Company?) 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People?s Republic of China Dear Members of the Board: We, Dr. Gang Yu, co-founder and co-chairman of the Company, Mr. Junling Liu, co-founder, co-chairman and chief executive officer of the Company (collectively, the ?Co-Founders?) and Shangh

September 9, 2022 SC 13D

YI / 111, Inc. / Gang Yu - SC 13D Activist Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13D Under the Securities Exchange Act of 1934 111, INC. (Name of Issuer) Class A ordinary shares, $0.00005 par value per share Class B ordinary shares, $0.00005 par value per share (Title of Class of Securities) 68247Q 102** (CUSIP Number) Gang Yu Xiaomei Michelle Song Infinity Cosmo Limited Junling Liu Sunny Bay Glob

September 9, 2022 EX-99.2

[signatures page follows]

EX-99.2 3 dp180155ex9902.htm EXHIBIT 99.2 EXHIBIT 99.2 September 9, 2022 Board of Directors (the “Board”) 111, Inc. (the “Company”) 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China Dear Members of the Board: We, Dr. Gang Yu, co-founder and co-chairman of the Company, Mr. Junling Liu, co- founder, co-chairman and chief executive officer of the Company (

September 8, 2022 LETTER

LETTER

United States securities and exchange commission logo September 8, 2022 Junling Liu Chief Executive Officer 111, Inc.

August 25, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2022 Commission file number: 001-38639 111, Inc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2022 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People?s Republic of China (Address of principal executive offices) Indicate by

August 25, 2022 EX-99.1

111, Inc. Announces Second Quarter 2022 Unaudited Financial Results

EX-99.1 2 dp179136ex9901.htm EXHIBIT 99.1 EXHIBIT 99.1 111, Inc. Announces Second Quarter 2022 Unaudited Financial Results SHANGHAI, August 25, 2022 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial resul

June 16, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2022 Commission file number: 001-38639 111, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of June 2022 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People?s Republic of China (Address of principal executive offices) Indicate by ch

June 16, 2022 EX-99.1

111, Inc. Announces First Quarter 2022 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces First Quarter 2022 Unaudited Financial Results SHANGHAI, June 16, 2022 /PRNewswire/ ? 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the first quarter ended March 31, 2022

May 5, 2022 EX-99.1

111, Inc. Provides Updates on its Status Under the Holding Foreign Companies Accountable Act

Exhibit 99.1 111, Inc. Provides Updates on its Status Under the Holding Foreign Companies Accountable Act SHANGHAI, May 5, 2022 /PRNewswire/ - 111 Inc. ( "111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company in China, today announced that on May 4th, 2022, the Securities and Exchange Commission (the "SEC") provisionally listed the Company as a "Commission-Identif

May 5, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2022 Commission file number: 001-38639 111, Inc. 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2022 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People?s Republic of China (Address of principal executive offices) Indicate by che

April 29, 2022 EX-13.1

Certification by Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.1 Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2021 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, Chief Executive Officer of the Company, certify, pursuant to

April 29, 2022 EX-13.2

Certification by Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.2 Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2021 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, acting in the capacity of Chief Financial Officer of the Com

April 29, 2022 EX-15.1

Consent of Maples and Calder (Hong Kong) LLP

Exhibit 15.1 Our refKKZ/742474-000001/19339623v1 111, Inc. 3-5/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China April 29, 2022 Dear Sir and/or Madam 111, Inc. We have acted as legal advisers as to the laws of the Cayman Islands to 111, Inc., an exempted limited liability company incorporated in the Cayman Islands (the “Company”), in connection with the fil

April 29, 2022 EX-15.2

Consent of Deloitte Touche Tohmatsu Certified Public Accountants LLP

Exhibit 15.2 ? ? CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM ? ? We consent to the incorporation by reference in Registration Statement No. 333-229313 on Form S-8 of our reports dated April 29, 2022, relating to the financial statements of 111, Inc. and the effectiveness of 111, Inc.?s internal control over financial reporting appearing in this Annual Report on Form 20-F for the year

April 29, 2022 EX-12.1

Certification by Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.1 Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

April 29, 2022 EX-12.2

Certification by Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.2 Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

April 29, 2022 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF

March 17, 2022 EX-99.1

111, Inc. Announces Fourth Quarter and Fiscal Year 2021 Financial Results

Exhibit 99.1 111, Inc. Announces Fourth Quarter and Fiscal Year 2021 Financial Results SHANGHAI, March 17, 2022 /PRNewswire/ ? 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the fourth quarter and fiscal

March 17, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2022 Commission file number: 001-38639 111, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2022 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People?s Republic of China (Address of principal executive offices) Indicate by c

March 1, 2022 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2022 Commission file number: 001-38639 111, Inc.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2022 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People?s Republic of China (Address of principal executive offices) Indicate by c

February 10, 2022 SC 13G/A

YI / 111, Inc. / ClearVue Partners, L.P. - SCHEDULE 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 3)* 111, Inc.** (Name of Issuer) Class A Ordinary Shares, par value US$0.00005 per share (Title of Class of Securities) 68247Q102 (CUSIP Number) December 31, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate

November 19, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2021 Commission file number: 001-38639 111, I

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2021 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People?s Republic of China (Address of principal executive offices) Indicate b

November 19, 2021 EX-99.1

111, Inc. Announces Third Quarter 2021 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Third Quarter 2021 Unaudited Financial Results SHANGHAI, November 19, 2021 /PRNewswire/ ? 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the third quarter ended September

September 7, 2021 EX-99.1

111 Inc. Announces $10 Million Share Repurchase Program

EX-99.1 2 dp157515ex9901.htm EXHIBIT 99.1 Exhibit 99.1 111 Inc. Announces $10 Million Share Repurchase Program SHANGHAI, Sept.7, 2021 /PRNewswire/ - 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced that its board of directors (the "Board") ha

September 7, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2021 Commission file number: 001-38639 111,

6-K 1 dp1575156k.htm FORM 6-K UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of September 2021 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principa

August 27, 2021 EX-99.1

111, Inc. Announces Second Quarter 2021 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Second Quarter 2021 Unaudited Financial Results SHANGHAI, August 27, 2021 /PRNewswire/ ? 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the second quarter ended June 30, 2

August 27, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2021 Commission file number: 001-38639 111, Inc

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2021 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People?s Republic of China (Address of principal executive offices) Indicate by

May 27, 2021 SC 13G/A

YI / 111, Inc. / Verlinvest Asia (HK) Ltd - SCHEDULE 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* 111, Inc. (Name of Issuer) Common Stock, par value of $0.00005 per share (Title of Class of Securities) 68247Q102** (CUSIP Number) March 2, 2021 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursu

May 27, 2021 EX-99.1

JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)(1)

Exhibit 99.1 JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)(1) The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing agreements. The undersigned a

May 19, 2021 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2021 Commission file number: 001-38639 111, Inc. 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2021 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People?s Republic of China (Address of principal executive offices) Indicate by che

May 19, 2021 EX-99.1

111, Inc. Announces First Quarter 2021 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces First Quarter 2021 Unaudited Financial Results SHANGHAI, May 19, 2021 /PRNewswire/ ? 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the first quarter ended March 31, 2021.

April 30, 2021 EX-4.27

English translation of Supplementary Agreement of Capital Increase Agreement in respect of Yao Fang Information Technology (Shanghai) Co., Ltd. dated August 26, 2020

Exhibit 4.27 Supplementary Agreement of Capital Increase Agreement in respect of Yao Fang Information Technology (Shanghai) Co., Ltd. ? Dated August 26, 2020 ? 1 This Supplementary Agreement of Capital Increase Agreement in respect of Yao Fang Information Technology (Shanghai) Co., Ltd. (this ?Supplementary Agreement?) is made in Shanghai as of August 26, 2020 by and among: A. Yao Fang Information

April 30, 2021 EX-15.2

Consent of Maples and Calder (Hong Kong) LLP

Exhibit 15.2 Our ref KKZ/742474-000001/19339623v1 111, Inc. 3-5/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China 30 April 2021 Dear Sir and/or Madam 111, Inc. We have acted as legal advisers as to the laws of the Cayman Islands to 111, Inc., an exempted limited liability company incorporated in the Cayman Islands (the “Company”), in connection with the fil

April 30, 2021 EX-13.2

Certification by Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.2 Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2020 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, acting in the capacity of Chief Financial Officer of the Com

April 30, 2021 EX-15.3

Consent of Deloitte Touche Tohmatsu Certified Public Accountants LLP

EX-15.3 12 yi-20201231xex15d3.htm EXHIBIT 15.3 Exhibit 15.3 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in Registration Statement No. 333-229313 on Form S-8 of our reports dated April 29, 2021, relating to the financial statements of 111, Inc. and the effectiveness of 111, Inc.’s internal control over financial reporting, appearing in this

April 30, 2021 EX-4.28

English translation of Capital Increase Agreement in respect of 1 Pharmacy Yao Fang Technology (Shanghai) Co., Ltd. dated December 14, 2020

Exhibit 4.28 Capital Increase Agreement in respect of 1 Pharmacy Yao Fang Technology (Shanghai) Co., Ltd. Dated December 14, 2020 Table of Contents Section Page 1. Definitions and Interpretation 5 2. Capital Increase 7 3. Payment 7 4. Warranties and Covenants 9 5. Completion of the Capital Increase 10 6. Rights and Obligations of the Shareholders 11 7. Employee Incentive Plan 18 8. Admission of Ne

April 30, 2021 EX-12.1

Certification by Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.1 Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

April 30, 2021 20-F

- FORM 20-F

Table of Contents ? ? ? UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.

April 30, 2021 EX-12.2

Certification by Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.2 Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1.I have reviewed this annual report on Form 20-F of 111, Inc.; 2.Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

April 30, 2021 EX-15.1

Consent of Commerce & Finance Law Offices

EX-15.1 10 yi-20201231xex15d1.htm EXHIBIT 15.1 Exhibit 15.1 中国北京市建国门外大街甲12号新华保险大厦6层100022 6/F, NCI Tower, A12 Jianguomenwai Avenue, Beijing 100022, China 电话 Tel: +86 10 6569 3399 传真 Fax: +86 10 6569 3838 电邮 Email: [email protected] 网址 Web: www.tongshang.com April 30, 2021 111, Inc. 3-4/F, No. 295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China Dear Sirs, We con

April 30, 2021 EX-4.26

English translation of Capital Increase Agreement in respect of Yao Fang Information Technology (Shanghai) Co., Ltd. dated August 10, 2020

EX-4.26 2 yi-20201231xex4d26.htm EXHIBIT 4.26 Exhibit 4.26 Capital Increase Agreement in respect of Yao Fang Information Technology (Shanghai) Co., Ltd. Dated August 10, 2020 Table of Contents Section Page 1. Definitions and Interpretation 2 2. Capital Increase 4 3. Payment 4 4. Warranties and Covenants 5 5. Completion of the Capital Increase 6 6. Rights and Obligations of the Shareholders 6 7. Em

April 30, 2021 EX-13.1

Certification by Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.1 Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the ?Company?) on Form 20-F for the year ended December 31, 2020 as filed with the Securities and Exchange Commission on the date hereof (the ?Report?), I, Junling Liu, Chief Executive Officer of the Company, certify, pursuant to

March 18, 2021 EX-99.1

111, Inc. Announces Fourth Quarter and Fiscal Year 2020 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Fourth Quarter and Fiscal Year 2020 Unaudited Financial Results SHANGHAI, March 18, 2021 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), "), a leading tech-enabled healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the fourth quart

March 18, 2021 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2021 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People?s Republic of China (Address of principal executive offices) Indicate by c

February 5, 2021 SC 13G/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* 111, Inc. (Name of Issuer) Class A Ordinary Shares, par value US$0.00005 per share (Title of Class of Se

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* 111, Inc. (Name of Issuer) Class A Ordinary Shares, par value US$0.00005 per share (Title of Class of Securities) 68247Q 102** (CUSIP Number) December 31, 2020 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate

December 22, 2020 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of December 2020 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate b

December 22, 2020 EX-99.1

111, Inc. Announces Additional Round of New Capital Injection Led by Esteemed List of Technology Investment Firms

Exhibit 99.1 111, Inc. Announces Additional Round of New Capital Injection Led by Esteemed List of Technology Investment Firms SHANGHAI, December 22, 2020 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading digital healthcare platform company committed to digitally connecting patients with medicine and healthcare services in China, today announced the successful completion of

November 19, 2020 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2020 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate b

November 19, 2020 EX-99.1

111, Inc. Announces Third Quarter 2020 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Third Quarter 2020 Unaudited Financial Results SHANGHAI, November 19, 2020 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a leading digital healthcare platform committed to digitally connecting patients with medicine and healthcare services in China, today announced its unaudited financial results for the third quarter ended September 30, 2020. Thi

November 6, 2020 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 OF THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2020 Commission file number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indicate b

August 20, 2020 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2020 Commission File Number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) I

August 20, 2020 EX-99.1

111, Inc. Announces New Capital Injection and Strategic Plan to Expand Access to China’s Capital Markets

Exhibit 99.1 111, Inc. Announces New Capital Injection and Strategic Plan to Expand Access to China’s Capital Markets · Completion of new capital injection in principal subsidiary Yao Fang Shanghai · Initiation to list shares of principal subsidiary Yao Fang Shanghai on the STAR Market · 111 firmly committed to maintaining Nasdaq listing status SHANGHAI, August 20, 2020 /PRNewswire/ – 111, Inc. ("

August 20, 2020 EX-99.2

111, Inc. Announces Second Quarter 2020 Unaudited Financial Results

Exhibit 99.2 111, Inc. Announces Second Quarter 2020 Unaudited Financial Results SHANGHAI, August 20, 2020 /PRNewswire/ – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a company dedicated to digitally connecting patients with drugs and healthcare services in China, today announced its unaudited financial results for the second quarter ended June 30, 2020. Second Quarter 2020 Highlights · Net re

May 21, 2020 EX-99.1

111, Inc. Announces First Quarter 2020 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces First Quarter 2020 Unaudited Financial Results SHANGHAI, May 21, 2020 (PR Newswire) – 111, Inc. ("111" or the "Company") (NASDAQ: YI), a Company dedicated to digitally connecting patients with drugs and healthcare services in China, today announced its unaudited financial results for the first quarter ended March 31, 2020. First Quarter 2020 Highlights (in comparis

May 21, 2020 6-K

Current Report of Foreign Issuer - FORM 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2020 Commission File Number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indi

April 16, 2020 EX-13.2

Certification by Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.2 Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2019 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Yang Chen, Chief Financial Officer of the Company, certify, pursuant to 1

April 16, 2020 20-F

YI / 111, Inc. 20-F - - 20-F

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 20-F (Mark One) o REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 or x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2019. or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d)

April 16, 2020 EX-15.1

Consent of Commerce & Finance Law Offices

Exhibit 15.1 [Commerce & Finance Law Offices Letterhead] April 16, 2020 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China Dear Sirs, We consent to the reference to our firm under the headings “Item 3. Key Information — D. Risk Factors,” and “Item 4. Information on the Company — C. Organizational Structure,” in 111, Inc.’s Annual Report on Form

April 16, 2020 EX-15.3

Consent of Deloitte Touche Tohmatsu Certified Public Accountants LLP

Exhibit 15.3 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in the Registration Statement No. 333-229313 on Form S-8 of our report dated April 16, 2020, relating to the financial statements of 111, Inc. appearing in this Annual Report on Form 20-F for the year ended December 31, 2019. /s/ Deloitte Touche Tohmatsu Certified Public Accountants L

April 16, 2020 EX-4.25

English translation of Amended Exclusive Support Services Agreement between Shanghai Yaowang E-Commerce Co., Ltd. and Yao Fang Information Technology (Shanghai) Co., Ltd. dated July 1, 2019

Exhibit 4.25 Amended Exclusive Support Services Agreement Between SHANGHAI YAOWANG E-COMMERCE CO., LTD. And YAO FANG INFORMATION TECHNOLOGY (SHANGHAI) CO., LTD. July 1, 2019 This Amended Exclusive Support Services Agreement (the “Agreement”) is concluded and signed on July 1, 2019 in Shanghai, the People’s Republic of China (“China”) by and between: SHANGHAI YAOWANG E-COMMERCE CO., LTD. (the “Oper

April 16, 2020 EX-12.2

Certification by Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.2 Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Yang Chen, certify that: 1. I have reviewed this annual report on Form 20-F of 111, Inc.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

April 16, 2020 EX-12.1

Certification by Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.1 Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1. I have reviewed this annual report on Form 20-F of 111, Inc.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the ci

April 16, 2020 EX-2.4

Description of Securities (incorporated by reference to Exhibit 2.4 of our Annual Report on Form 20-F (file no. 001-38639) filed with the Securities and Exchange Commission on April 16, 2020)

Exhibit 2.4 Description of Rights of Each Class of Securities Registered under Section 12 of the Securities Exchange Act of 1934 (the “Exchange Act”) American Depositary Shares (“ADSs”) each representing two Class A ordinary shares of 111, Inc., (the “we,” “our,” “our company,” or “us”) are listed and traded on the Nasdaq Global Market and, in connection with this listing (but not for trading), th

April 16, 2020 EX-4.23

English translation of Amended Exclusive Support Services Agreement between Guangdong Yihao Pharmacy Co., Ltd. and Yao Fang Information Technology (Shanghai) Co., Ltd. dated July 1, 2019

Exhibit 4.23 Amended Exclusive Support Services Agreement Between GUANGDONG YIHAO PHARMACY CO., LTD. And YAO FANG INFORMATION TECHNOLOGY (SHANGHAI) CO., LTD. July 1, 2019 This Amended Exclusive Support Services Agreement (the “Agreement”) is concluded and signed on July 1, 2019 in Shanghai, the People’s Republic of China (“China”) by and between: GUANGDONG YIHAO PHARMACY CO., LTD. (the “Operator”)

April 16, 2020 EX-13.1

Certification by Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.1 Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2019 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, Chief Executive Officer of the Company, certify, pursuant to

April 16, 2020 EX-15.2

Consent of Maples and Calder (Hong Kong) LLP

EX-15.2 12 a19-266481ex15d2.htm EX-15.2 Exhibit 15.2 [Maples and Calder (Hong Kong) LLP Letterhead] Our ref KKZ/742474-000001/16431314v1 111, Inc. 3-5/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China 16 April 2020 Dear Sir and/or Madam 111, Inc. We have acted as legal advisers as to the laws of the Cayman Islands to 111, Inc., an exempted limited liability

April 16, 2020 EX-4.24

English translation of Amended Exclusive Support Services Agreement between Guangdong Yihao Pharmaceutical Chain Co., Ltd. and Yao Fang Information Technology (Shanghai) Co., Ltd. dated July 1, 2019

Exhibit 4.24 Amended Exclusive Support Services Agreement Between GUANGDONG YIHAO PHARMACEUTICAL CHAIN CO., LTD. And YAO FANG INFORMATION TECHNOLOGY (SHANGHAI) CO., LTD. July 1, 2019 This Amended Exclusive Support Services Agreement (the “Agreement”) is concluded and signed on July 1, 2019 in Shanghai, the People’s Republic of China (“China”) by and between: GUANGDONG YIHAO PHARMACEUTICAL CHAIN CO

March 13, 2020 EX-99.1

111, Inc. Announces Fourth Quarter and Fiscal Year 2019 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Fourth Quarter and Fiscal Year 2019 Unaudited Financial Results SHANGHAI, CHINA - March 12, 2020 - 111, Inc. (“111” or the “Company”) (NASDAQ: YI), a leading integrated online and offline healthcare platform in China, today announced its unaudited financial results for the fourth quarter and fiscal year ended December 31, 2019. Fourth Quarter 2019 Highlights · Net

March 13, 2020 6-K

YI / 111, Inc. 6-K - Current Report of Foreign Issuer - 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2020 Commission File Number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) In

February 24, 2020 SC 13G/A

YI / 111, Inc. / Clearvue Partners, L.p. - SCHEDULE 13G/A Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* 111, Inc. (Name of Issuer) Class A Ordinary Shares, par value US$0.00005 per share (Title of Class of Securities) 68247Q 102** (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate

January 29, 2020 SC 13G/A

SECURITIES AND EXCHANGE COMMISSION

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* 111, Inc. (Name of Issuer) Class A ordinary shares, $0.00005 par value per share (Title of Class of Securities) 68247Q 102** (CUSIP Number) December 31, 2019 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursua

January 29, 2020 EX-99.A

JOINT FILING AGREEMENT

EXHIBIT A JOINT FILING AGREEMENT In accordance with Rule 13d-1(k) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree to the joint filing with all other Reporting Persons (as such term is defined in the Schedule 13G referred to below) on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the shares of Class A ordinary shares, par value of $0.

November 15, 2019 6-K

YI / 111, Inc. 6-K - Current Report of Foreign Issuer - 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2019 Commission File Number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices)

November 15, 2019 EX-99.1

111, Inc. Announces Third Quarter 2019 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Third Quarter 2019 Unaudited Financial Results SHANGHAI, CHINA — November 14, 2019 - 111, Inc. (“111” or the “Company”) (NASDAQ: YI), a leading integrated online and offline healthcare platform in China, today announced its unaudited financial results for the third quarter ended September 30, 2019. Third Quarter 2019 Highlights · Net revenues were RMB1.11 billion (

August 19, 2019 6-K

YI / 111, Inc. 6-K - Current Report of Foreign Issuer - 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of August 2019 Commission File Number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) I

August 19, 2019 EX-99.1

111, Inc. Announces Second Quarter 2019 Unaudited Financial Results and US$10 Million Share Repurchase Program

Exhibit 99.1 111, Inc. Announces Second Quarter 2019 Unaudited Financial Results and US$10 Million Share Repurchase Program SHANGHAI, Aug. 15, 2019 /PRNewswire/ — 111, Inc. (“111” or the “Company”) (NASDAQ: YI), a leading integrated online and offline healthcare platform in China, today announced its unaudited financial results for the second quarter ended June 30, 2019 and US$10 million share rep

May 17, 2019 6-K

YI / 111, Inc. 6-K Current Report of Foreign Issuer 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2019 Commission File Number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indi

May 17, 2019 EX-99.1

111 Announces Changes to its Board of Directors

Exhibit 99.1 111 Announces Changes to its Board of Directors SHANGHAI, May 16, 2019 — 111, Inc. (NASDAQ: YI) (“111” or the “Company”), a leading integrated online and offline healthcare platform, today announced that Dr. Leon Lian Yong Chen has been appointed as a new member to the board of directors. Meanwhile, Mr. Harry Chi Hui will no longer serve as a director for personal reasons. Both change

May 16, 2019 6-K

YI / 111, Inc. 6-K Current Report of Foreign Issuer 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of May 2019 Commission File Number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) Indi

May 16, 2019 EX-99.1

111, Inc. Announces First Quarter 2019 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces First Quarter 2019 Unaudited Financial Results SHANGHAI, CHINA — May 16, 2019 - 111, Inc. (“111” or the “Company”) (NASDAQ: YI), a leading integrated online and offline healthcare platform in China, today announced its unaudited financial results for the first quarter ended March 31, 2019. First Quarter 2019 Highlights · Net revenues were RMB655.6 million (US$97.7

April 10, 2019 EX-15.1

Consent of Commerce & Finance Law Offices

Exhibit 15.1 [Commerce & Finance Law Offices Letterhead] April 10, 2019 111, Inc. 3-5/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China Dear Sirs, We consent to the reference to our firm under the headings “Item 3. Key Information—D. Risk Factors,” and “Item 4. Information on the Company—C. Organizational Structure” in 111, Inc.’s Annual Report on Form 20-F

April 10, 2019 20-F

YI / 111, Inc. 20-F

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 20-F (Mark One) o REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 or x ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2018. or o TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d)

April 10, 2019 EX-15.2

Consent of Maples and Calder (Hong Kong) LLP

Exhibit 15.2 [Maples and Calder (Hong Kong) LLP Letterhead] Our ref KKZ/742474-000001/14284628v2 111, Inc. 3-5/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China 10 April 2019 Dear Sirs 111, Inc. We have acted as legal advisers as to the laws of the Cayman Islands to 111, Inc., an exempted limited liability company incorporated in the Cayman Islands (the “Co

April 10, 2019 EX-13.2

Certification by Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.2 Certification by the Principal Financial Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2018 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Yang Chen, Chief Financial Officer of the Company, certify, pursuant to 1

April 10, 2019 EX-13.1

Certification by Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

Exhibit 13.1 Certification by the Principal Executive Officer Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2018 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, Chief Executive Officer of the Company, certify, pursuant to

April 10, 2019 EX-12.2

Certification by Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.2 Certification by the Principal Financial Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Yang Chen, certify that: 1. I have reviewed this annual report on Form 20-F of 111, Inc.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circ

April 10, 2019 EX-12.1

Certification by Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002

Exhibit 12.1 Certification by the Principal Executive Officer Pursuant to Section 302 of the Sarbanes-Oxley Act of 2002 I, Junling Liu, certify that: 1. I have reviewed this annual report on Form 20-F of 111, Inc.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the ci

April 10, 2019 EX-15.3

Consent of Deloitte Touche Tohmatsu Certified Public Accountants LLP

Exhibit 15.3 CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in Registration Statement No. 333-229313 on Form S-8 of our report dated April 9, 2019, relating to the consolidated financial statements and financial statement schedule of 111, Inc., its subsidiaries, variable interest entities (“VIEs”) and VIEs’ subsidiaries (collectively, the “Gro

March 8, 2019 EX-99.1

111, Inc. Announces Fourth Quarter and Fiscal Year 2018 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Fourth Quarter and Fiscal Year 2018 Unaudited Financial Results SHANGHAI, CHINA - March 7, 2019 - 111, Inc. (“111” or the “Company”) (NASDAQ: YI), a leading integrated online and offline healthcare platform in China, today announced its unaudited financial results for the fourth quarter and fiscal year ended December 31, 2018. Fourth Quarter 2018 Highlights · Net r

March 8, 2019 6-K

YI / 111, Inc. 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of March 2019 Commission File Number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices) In

February 27, 2019 EX-99.1

111, Inc. Announces the Appointment of a New Chief Financial Officer

EX-99.1 2 a19-55461ex99d1.htm EX-99.1 Exhibit 99.1 111, Inc. Announces the Appointment of a New Chief Financial Officer SHANGHAI, China, February 27, 2019 (GLOBE NEWSWIRE) - 111, Inc. (Nasdaq: YI) (“111” or the “Company”), a leading integrated online and offline healthcare platform, today announced that Mr. Yang Chen has been appointed as Chief Financial Officer, effective immediately on February

February 27, 2019 6-K

YI / 111, Inc. 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of February 2019 Commission File Number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices)

February 14, 2019 EX-99.1

Joint Filing Agreement

EXHIBIT 99.1 Joint Filing Agreement Pursuant to Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned agree that the Statement on Schedule 13G to which this Exhibit is attached is filed on behalf of each of them. Each of them is individually eligible to use the Schedule 13G to which this Exhibit is attached. Each of them is responsible for the timely f

February 14, 2019 SC 13G

SECURITIES AND EXCHANGE COMMISSION

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 111, INC. (Name of Issuer) Class A ordinary shares, par value $0.00005 per share (Title of Class of Securities) 68247Q 102** (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Sc

February 11, 2019 SC 13G

YI / 111, Inc. / Clearvue Partners, L.p. - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.)* 111, Inc.** (Name of Issuer) Class A Ordinary Shares, par value US$0.00005 per share (Title of Class of Securities) 68247Q102 (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate th

January 28, 2019 SC 13G

SECURITIES AND EXCHANGE COMMISSION

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* 111, Inc. (Name of Issuer) Class A ordinary shares, $0.00005 par value per share (Title of Class of Securities) 68247Q 102** (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuan

January 28, 2019 SC 13G

SECURITIES AND EXCHANGE COMMISSION

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* 111, Inc. (Name of Issuer) Class A ordinary shares, $0.00005 par value per share (Title of Class of Securities) 68247Q 102** (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuan

January 28, 2019 EX-99.A

JOINT FILING AGREEMENT

EXHIBIT A JOINT FILING AGREEMENT In accordance with Rule 13d-1(k) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree to the joint filing with all other Reporting Persons (as such term is defined in the Schedule 13G referred to below) on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the shares of Class A ordinary shares, par value of $0.

January 28, 2019 EX-99.A

JOINT FILING AGREEMENT

EXHIBIT A JOINT FILING AGREEMENT In accordance with Rule 13d-1(k) promulgated under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree to the joint filing with all other Reporting Persons (as such term is defined in the Schedule 13G referred to below) on behalf of each of them of a statement on Schedule 13G (including amendments thereto) with respect to the shares of Class A ordinary shares, par value of $0.

January 22, 2019 EX-4.3

Deposit Agreement between the Registrant, the Bank of New York Mellon and all owner and holders from time to time of ADSs issued thereunder, dated September 12, 2018 (incorporated by reference to Exhibit 4.3 of our registration statement on Form S-8 (file no. 333-229313), as amended, initially filed with the Securities and Exchange Commission on January 22, 2019)

Exhibit 4.3 111, INC. AND THE BANK OF NEW YORK MELLON As Depositary AND OWNERS AND HOLDERS OF AMERICAN DEPOSITARY SHARES Deposit Agreement September 12, 2018 TABLE OF CONTENTS ARTICLE 1. DEFINITIONS 1 SECTION 1.1. American Depositary Shares 1 SECTION 1.2. Commission 2 SECTION 1.3. Company 2 SECTION 1.4. Custodian 2 SECTION 1.5. Delisting Event 2 SECTION 1.6. Deliver; Surrender 2 SECTION 1.7. Depos

January 22, 2019 S-8

YI / 111, Inc. S-8

As filed with the Securities and Exchange Commission on January 22, 2019 Registration No.

January 18, 2019 EX-99.1

111, Inc. Announces Management and Board Changes

Exhibit 99.1 111, Inc. Announces Management and Board Changes SHANGHAI, China, Jan. 18, 2019 (GLOBE NEWSWIRE) — 111, Inc. (NASDAQ: YI) (“111” or the “Company”), a leading integrated online and offline healthcare platform in China, today announced that Mr. Weihao Xu has resigned as Chief Financial Officer and director for personal reasons. The Company has begun a process to appoint a successor to M

January 18, 2019 6-K

YI / 111, Inc. 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of January 2019 Commission File Number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices)

January 18, 2019 SC 13G

YI / 111, Inc. / Verlinvest Asia (hk) Ltd - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934* 111, Inc. (Name of Issuer) Class A ordinary shares, par value $0.00005 per share (Title of Class of Securities) 68247Q102** (CUSIP Number) December 31, 2018 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to

January 18, 2019 EX-99.1

JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)(1)

Exhibit 99.1 JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)(1) The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing agreements. The undersigned a

November 9, 2018 6-K

YI / 111, Inc. 6-K (Current Report of Foreign Issuer)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 For the month of November 2018 Commission File Number: 001-38639 111, Inc. 3-4/F, No.295 ZuChongZhi Road, Pudong New Area Shanghai, 201203 The People’s Republic of China (Address of principal executive offices)

November 9, 2018 EX-99.1

111, Inc. Announces Third Quarter 2018 Unaudited Financial Results

Exhibit 99.1 111, Inc. Announces Third Quarter 2018 Unaudited Financial Results SHANGHAI, CHINA - November 8, 2018 - 111, Inc. (“111” or the “Company”) (NASDAQ: YI), a leading integrated online and offline healthcare platform in China, today announced its unaudited financial results for the third quarter ended September 30, 2018. Third Quarter 2018 Highlights · Net revenues were RMB497.6 million (

September 13, 2018 424B4

7,175,000 American Depositary Shares 111, Inc. Representing 14,350,000 Class A Ordinary Shares

Use these links to rapidly review the document TABLE OF CONTENTS INDEX TO CONSOLIDATED FINANCIAL STATEMENTS Table of Contents Filed Pursuant to Rule 424b(4) Registration No.

September 7, 2018 CORRESP

YI / 111, Inc. CORRESP

September 7, 2018 VIA EDGAR Mr. John Reynolds Ms. Brigitte Lippman Mr. Jonathan Burr Mr. Blaise Rhodes Mr. Raj Rajan Division of Corporation Finance Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 U. S. A. Re: 111, Inc. (CIK No. 0001738906) Registration Statement on Form F-1 (File No. 333-226849) Registration Statement on Form 8-A (File No. 001-38639) Dear Ladies and G

September 7, 2018 CORRESP

YI / 111, Inc. CORRESP

J.P. Morgan Securities LLC 383 Madison Avenue New York, New York 10179 Citigroup Global Markets Inc. 388 Greenwich Street New York, New York 10013 China International Capital Corporation Hong Kong Securities Limited 29th Floor, One International Finance Centre 1 Harbour View Street, Central Hong Kong September 7, 2018 Securities and Exchange Commission Division of Corporation Finance 100 F Street,

September 7, 2018 FWP

111, Inc.

QuickLinks - Click here to rapidly navigate through this document Issuer Free Writing Prospectus Filed Pursuant to Rule 433 Registration No.

September 7, 2018 EX-1.1

Form of Underwriting Agreement

Exhibit 1.1 111, Inc. [?] American Depositary Shares Representing [?] Class A Ordinary Shares Underwriting Agreement [?], 2018 J.P. Morgan Securities LLC Citigroup Global Markets Inc. China International Capital Corporation Hong Kong Securities Limited As Representatives of the several Underwriters listed in Schedule 1 hereto c/o J.P. Morgan Securities LLC 383 Madison Avenue New York, New York 101

September 7, 2018 F-1/A

As filed with the Securities and Exchange Commission on September 7, 2018

Use these links to rapidly review the document TABLE OF CONTENTS INDEX TO CONSOLIDATED FINANCIAL STATEMENTS As filed with the Securities and Exchange Commission on September 7, 2018 Registration No.

September 7, 2018 CORRESP

YI / 111, Inc. CORRESP

DIRECT DIAL AFFILIATE OFFICES (852) 3740-4863 SKADDEN, ARPS, SLATE, MEAGHER & FLOM DIRECT FAX 世達國際律師事務所 BOSTON (852) 3910-4863 42/F, EDINBURGH TOWER, THE LANDMARK CHICAGO EMAIL ADDRESS 15 QUEEN’S ROAD CENTRAL, HONG KONG HOUSTON JULIE.

September 5, 2018 LETTER

LETTER

Mail Stop 3561 September 5, 2018 Via E-mail Weihao Xu Chief Financial Officer 111, Inc.

September 5, 2018 TEXT-EXTRACT

YI / 111, Inc. TEXT-EXTRACT

Mail Stop 3561 September 5, 2018 Via E-mail Weihao Xu Chief Financial Officer 111, Inc.

September 4, 2018 CERT

CERT

The Nasdaq Stock Market LLC, 805 King Farm Blvd., Rockville, MD 20850 William Slattery, CFA Vice President Listing Qualifications Electronic Mail Only September 4, 2018 Division of Corporation Finance U.S. Securities and Exchange Commission 100 F Street, N.E. Washington, D.C. 20549 Division of Corporate Finance: This is to certify that on August 29, 2018, The Nasdaq Stock Market (the "Exchange") r

August 29, 2018 8-A12B

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 111, Inc. (Exact name of registrant as specifie

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 111, Inc. (Exact name of registrant as specified in its charter) Cayman Islands Not Applicable (State of incorporation or organization) (I.R.S. Employer Identification No.) 3-4/F, No.295 ZuChongZhi

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